Brief Definitive Report INFECTION OF RABBITS WITH HUMAN IMMUNODEFICIENCY VIRUS 1 A Small Animal Model for Acquired Immunodeficiency Syndrome
نویسندگان
چکیده
Human immunodeficiency virus (HIV1) has been associated with acquired immunodeficiency syndrome (AIDS) in man (1-4) . Development of successful immunization and/or therapeutic regimens for AIDS has been hampered by the lack of easily manipulated animal models for HIV-1 infection (5) . Recent reports (6, 7) suggest that rabbits may be useful for the study of HIV-1 infection . In the present study rabbits previously infected with HTLV1, as well as normal rabbits, were injected with a human T cell line infected with HIV-1 . Both groups showed signs of HIV-1 infection, which were substantiated using serologic, biologic, and molecular analyses .
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